methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

Base Information

Chemical Name:methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate
CAS No.:1425924-30-6
Molecular Formula:C₂₉H₅₀N₄O₅Si
Molecular Weight:562.825
Hs Code.:

Synonyms:methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

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Chemical Property of methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

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Technology Process of methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

There total 10 articles about methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1425924-29-3
methyl (S)-1-{(S)-2-[(S)-2-(benzyloxycarbonylamino)-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

: 1425924-30-6
methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; for 19h; under 760.051 Torr;
DOI:10.1021/jo3027214

Reference yield:

: 1425924-25-9
tert-butyl (S)-2-amino-3-[3-(triisopropylsilyloxy)phenyl]propanoate

: 1425924-30-6
methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.75 h / 20 °C / Inert atmosphere

2: methoxybenzene; trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol / 19 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo3027214

Reference yield:

: 1425924-27-1
tert-butyl (S)-{2-[(S)-2-(benzyloxycarbonylamino)-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]}propanoate

: 1425924-30-6
methyl (S)-1-{(S)-2-[(S)-2-amino-3-(methyl)butanamido]-3-[3-(triisopropylsilyloxy)phenyl]propanoyl}hexahydropyridazine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: methoxybenzene; trifluoroacetic acid / dichloromethane / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol / 19 h / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo3027214