1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone

Base Information

Chemical Name:1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone
CAS No.:357436-36-3
Molecular Formula:C₃₂H₃₁NO₇
Molecular Weight:541.601
Hs Code.:

Synonyms:1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone

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Chemical Property of 1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone

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Technology Process of 1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone

There total 6 articles about 1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 357436-33-0
1-(2-O,4-C-methylene-β-D-ribofuranosyl)-2-pyridone

: 357436-36-3
1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone

Guidance literature:: In pyridine; at 20 ℃;
DOI:10.1002/1521-3773(20010601)40:11<2079::AID-ANIE2079>3.0.CO;2-Z

Reference yield: 96.0%

: 357436-36-3
1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone

Guidance literature:

Reference yield:

: 142-08-5,1199357-22-6
2-Pyridone

: 357436-36-3
1-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]-2-pyridone

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 2 h / Heating

1.2: 74 percent / TMSOTf / 1,2-dichloro-ethane / 4 h / Heating

2.1: 100 percent / K₂CO₃ / methanol / 17 h / 20 °C

3.1: 95 percent / cyclohexene / 20percent palladium hydroxide/C / ethanol / 1.5 h / Heating

4.1: 96 percent / pyridine / 1 h / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; potassium carbonate; cyclohexene; 20percent palladium hydroxide/C; In methanol; ethanol; 1,2-dichloro-ethane;
DOI:10.1002/1521-3765(20021018)8:20<4796::AID-CHEM4796>3.0.CO;2-O