C₄₄H₅₂N₈O₁₀S₂

Base Information

Chemical Name:C₄₄H₅₂N₈O₁₀S₂
CAS No.:1391396-76-1
Molecular Formula:C₄₄H₅₂N₈O₁₀S₂
Molecular Weight:917.076
Hs Code.:

C<sub>44</sub>H<sub>52</sub>N<sub>8</sub>O<sub>10</sub>S<sub>2</sub>

Synonyms:C₄₄H₅₂N₈O₁₀S₂

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Chemical Property of C₄₄H₅₂N₈O₁₀S₂

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Technology Process of C₄₄H₅₂N₈O₁₀S₂

There total 19 articles about C₄₄H₅₂N₈O₁₀S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1064764-00-6
methyl 2-(2-methyl-2-tert-butoxy-1-tert-butoxycarbonylamino-ethyl)-oxazole-4-carboxylate

: 1391396-76-1
C₄₄H₅₂N₈O₁₀S₂

Guidance literature:: Multi-step reaction with 14 steps

1.1: lithium hydroxide / methanol; dichloromethane / 8 h / 20 °C

1.2: pH 1 / Acidic conditions

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol

4.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C / Inert atmosphere

5.1: potassium carbonate / dichloromethane / -78 - 20 °C / Inert atmosphere

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.25 h / -20 °C / Inert atmosphere

6.2: 12 h / -20 - 20 °C / Inert atmosphere

7.1: ammonium hydroxide / methanol; water / 20 °C / Sonication

8.1: Lawessons reagent / 1,2-dimethoxyethane / 60 °C / Inert atmosphere

9.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

9.2: 3 h / 0 °C / Inert atmosphere

9.3: 3 h / 20 °C / Inert atmosphere

10.1: ammonium hydroxide / methanol; water / 20 °C / Sonication

11.1: Lawessons reagent / 1,2-dimethoxyethane / 60 °C / Inert atmosphere

12.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

12.2: 3 h / 0 °C / Inert atmosphere

12.3: 3 h / 20 °C / Inert atmosphere

13.1: lithium hydroxide / methanol; dichloromethane / 8 h / 20 °C

13.2: pH 1 / Acidic conditions

14.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With Lawessons reagent; ammonium hydroxide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 9.1: Hantzsch thiazole synthesis / 9.2: Hantzsch thiazole synthesis / 9.3: Hantzsch thiazole synthesis / 12.1: Hantzsch thiazole synthesis / 12.2: Hantzsch thiazole synthesis / 12.3: Hantzsch thiazole synthesis;
DOI:10.1016/j.tetlet.2012.05.105

Reference yield:

: 1391396-36-3
C₂₇H₃₉N₃O₈

: 1391396-76-1
C₄₄H₅₂N₈O₁₀S₂

Guidance literature:: Multi-step reaction with 12 steps

1.1: palladium 10% on activated carbon; hydrogen / ethanol

2.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C / Inert atmosphere

3.1: potassium carbonate / dichloromethane / -78 - 20 °C / Inert atmosphere

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.25 h / -20 °C / Inert atmosphere

4.2: 12 h / -20 - 20 °C / Inert atmosphere

5.1: ammonium hydroxide / methanol; water / 20 °C / Sonication

6.1: Lawessons reagent / 1,2-dimethoxyethane / 60 °C / Inert atmosphere

7.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

7.2: 3 h / 0 °C / Inert atmosphere

7.3: 3 h / 20 °C / Inert atmosphere

8.1: ammonium hydroxide / methanol; water / 20 °C / Sonication

9.1: Lawessons reagent / 1,2-dimethoxyethane / 60 °C / Inert atmosphere

10.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

10.2: 3 h / 0 °C / Inert atmosphere

10.3: 3 h / 20 °C / Inert atmosphere

11.1: lithium hydroxide / methanol; dichloromethane / 8 h / 20 °C

11.2: pH 1 / Acidic conditions

12.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With Lawessons reagent; ammonium hydroxide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 7.1: Hantzsch thiazole synthesis / 7.2: Hantzsch thiazole synthesis / 7.3: Hantzsch thiazole synthesis / 10.1: Hantzsch thiazole synthesis / 10.2: Hantzsch thiazole synthesis / 10.3: Hantzsch thiazole synthesis;
DOI:10.1016/j.tetlet.2012.05.105

Reference yield:

: 1064763-79-6
Boc-L-Thr(t-Bu)-L-Ser-OMe

: 1391396-76-1
C₄₄H₅₂N₈O₁₀S₂

Guidance literature:: Multi-step reaction with 17 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C / Inert atmosphere

2.1: potassium carbonate / dichloromethane / -78 - 20 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.25 h / -20 °C / Inert atmosphere

3.2: 12 h / -20 - 20 °C / Inert atmosphere

4.1: lithium hydroxide / methanol; dichloromethane / 8 h / 20 °C

4.2: pH 1 / Acidic conditions

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

6.1: palladium 10% on activated carbon; hydrogen / ethanol

7.1: diethylamino-sulfur trifluoride / dichloromethane / 1 h / -78 °C / Inert atmosphere

8.1: potassium carbonate / dichloromethane / -78 - 20 °C / Inert atmosphere

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 0.25 h / -20 °C / Inert atmosphere

9.2: 12 h / -20 - 20 °C / Inert atmosphere

10.1: ammonium hydroxide / methanol; water / 20 °C / Sonication

11.1: Lawessons reagent / 1,2-dimethoxyethane / 60 °C / Inert atmosphere

12.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

12.2: 3 h / 0 °C / Inert atmosphere

12.3: 3 h / 20 °C / Inert atmosphere

13.1: ammonium hydroxide / methanol; water / 20 °C / Sonication

14.1: Lawessons reagent / 1,2-dimethoxyethane / 60 °C / Inert atmosphere

15.1: potassium hydrogencarbonate / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

15.2: 3 h / 0 °C / Inert atmosphere

15.3: 3 h / 20 °C / Inert atmosphere

16.1: lithium hydroxide / methanol; dichloromethane / 8 h / 20 °C

16.2: pH 1 / Acidic conditions

17.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

With Lawessons reagent; ammonium hydroxide; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; potassium carbonate; potassium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; 12.1: Hantzsch thiazole synthesis / 12.2: Hantzsch thiazole synthesis / 12.3: Hantzsch thiazole synthesis / 15.1: Hantzsch thiazole synthesis / 15.2: Hantzsch thiazole synthesis / 15.3: Hantzsch thiazole synthesis;
DOI:10.1016/j.tetlet.2012.05.105