2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

Base Information

Chemical Name:2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide
CAS No.:344569-50-2
Molecular Formula:C₂₈H₄₁NO₅Si
Molecular Weight:499.723
Hs Code.:

2-{6-[3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-<i>N</i>,<i>N</i>-dimethyl-acetamide

Synonyms:2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

Suppliers and Price of 2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

There total 11 articles about 2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 344569-48-8
2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,6-dihydro-2H-pyran-3-yl}-N,N-dimethyl-acetamide

: 344569-50-2
2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

Guidance literature:: With osmium(VIII) oxide; N-methyl-2-indolinone; In tetrahydrofuran; water;
DOI:10.1016/S0040-4039(01)00440-3

Reference yield:

: 221015-49-2
(1R,2S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-ol

: 344569-50-2
2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / H₂ / PtO₂ / ethyl acetate

2: 91 percent / NaH / tetrahydrofuran; dimethylformamide

3: TBAF / tetrahydrofuran

4: I₂; PPh₃; imidazole / toluene

5: 83 percent / Zn; AcOH / methanol / 20 °C

6: 96 percent / NaBH₄ / ethanol

7: 99 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

8: 100 percent / imidazole / dimethylformamide

9: 87 percent / diphenyl ether / 280 °C / Heating

10: 100 percent / OsO₄; NMO / H₂O; tetrahydrofuran

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; Grubbs catalyst first generation; N-methyl-2-indolinone; tetrabutyl ammonium fluoride; hydrogen; iodine; sodium hydride; acetic acid; triphenylphosphine; zinc; platinum(IV) oxide; In tetrahydrofuran; methanol; diphenylether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 9: Eschenmoser-Claisen rearrangement;
DOI:10.1016/S0040-4039(01)00440-3

Reference yield:

: 221015-46-9
(1S,5S,7R)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,8-dioxa-bicyclo[3.2.1]oct-3-en-2-one

: 344569-50-2
2-{6-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-4,5-dihydroxy-tetrahydro-pyran-3-yl}-N,N-dimethyl-acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 95 percent / NaBH₄; CeCl₃ / methanol

2: 95 percent / H₂ / PtO₂ / ethyl acetate

3: 91 percent / NaH / tetrahydrofuran; dimethylformamide

4: TBAF / tetrahydrofuran

5: I₂; PPh₃; imidazole / toluene

6: 83 percent / Zn; AcOH / methanol / 20 °C

7: 96 percent / NaBH₄ / ethanol

8: 99 percent / Grubbs' catalyst / CH₂Cl₂ / Heating

9: 100 percent / imidazole / dimethylformamide

10: 87 percent / diphenyl ether / 280 °C / Heating

11: 100 percent / OsO₄; NMO / H₂O; tetrahydrofuran

With 1H-imidazole; sodium tetrahydroborate; osmium(VIII) oxide; Grubbs catalyst first generation; N-methyl-2-indolinone; cerium(III) chloride; tetrabutyl ammonium fluoride; hydrogen; iodine; sodium hydride; acetic acid; triphenylphosphine; zinc; platinum(IV) oxide; In tetrahydrofuran; methanol; diphenylether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 10: Eschenmoser-Claisen rearrangement;
DOI:10.1016/S0040-4039(01)00440-3