Technology Process of (1R,5R)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hex-5-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-5-methyl-2-methylene-cyclohexanol
There total 9 articles about (1R,5R)-3-[2-[(1R,3aS,7aR)-1-((R)-1,5-Dimethyl-hex-5-enyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-5-methyl-2-methylene-cyclohexanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 66 percent / iodine, triphenylphosphine, triethylamine / acetonitrile / 14 h / Heating
2: 67 percent / sodium borohydride / ethanol / 0.33 h
3: imidazole
4: 1.) tert-butyllithium, 2.) CuI, (n-Bu)3P, 3.) (n-Bu)4NF
5: 2,2,4-trimethyl-pentane / 11 h / 100 °C
With
1H-imidazole; sodium tetrahydroborate; copper(l) iodide; tributylphosphine; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; triethylamine; triphenylphosphine;
In
2,2,4-trimethylpentane; ethanol; acetonitrile;
DOI:10.1021/ja00386a042
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 94 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH2Cl2 / 4.5 h
2: 93 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) room temperature, 1 h
3: 70 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 2.) room temperature, 3 h
4: 1.) tert-butyllithium, 2.) CuI, (n-Bu)3P, 3.) (n-Bu)4NF
5: 2,2,4-trimethyl-pentane / 11 h / 100 °C
With
copper(l) iodide; dipyridinium dichromate; n-butyllithium; tributylphosphine; tetrabutyl ammonium fluoride; tert.-butyl lithium; pyridinium trifluroacetate;
In
tetrahydrofuran; 2,2,4-trimethylpentane; dichloromethane;
DOI:10.1021/ja00386a042
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) room temperature, 1 h
2: 70 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 2.) room temperature, 3 h
3: 1.) tert-butyllithium, 2.) CuI, (n-Bu)3P, 3.) (n-Bu)4NF
4: 2,2,4-trimethyl-pentane / 11 h / 100 °C
With
copper(l) iodide; n-butyllithium; tributylphosphine; tetrabutyl ammonium fluoride; tert.-butyl lithium;
In
tetrahydrofuran; 2,2,4-trimethylpentane;
DOI:10.1021/ja00386a042
