Multi-step reaction with 11 steps
1.1: thionyl chloride / benzene / 3.5 h / 75 °C
2.1: ammonia / tetrahydrofuran / 12 h / 0 - 20 °C
3.1: hydrogen / palladium 10% on activated carbon / methanol; 1,2-dimethoxyethane / 16 h / 20 °C
4.1: pyridine / chloroform / 5 h / 20 °C
5.1: sodium hydroxide / water / 16 h / Heating / reflux
5.2: pH 7
6.1: methanesulfonic acid; L-methionine / 24 h / 100 °C
7.1: pyridine / 3 h / 105 °C
8.1: thionyl chloride; N,N-dimethyl-formamide / 16 h / Heating / reflux
8.2: 20 °C
9.1: isopropyl alcohol / 2 h / 95 °C
10.1: methanol; ammonia; water / 16 h / 20 °C
11.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C
With
pyridine; methanol; sodium hydroxide; thionyl chloride; methanesulfonic acid; L-methionine; ammonia; water; hydrogen; potassium carbonate; N,N-dimethyl-formamide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol; benzene;