(s)-2-Cyclohexyl-2-phenylglycolic acid

Base Information

• Chemical Name: (s)-2-Cyclohexyl-2-phenylglycolic acid
• CAS No.: 20585-34-6
• Molecular Formula: C14H18 O3
• Molecular Weight: 234.295
• Hs Code.: 2918199090
• European Community (EC) Number: 675-871-9
• UNII: 950K161U77
• Nikkaji Number: J1.044.762C
• Wikidata: Q27271720
• Mol file: 20585-34-6.mol

Synonyms:(S)-2-cyclohexyl-2-phenylglycolic acid

Chemical Property of (s)-2-Cyclohexyl-2-phenylglycolic acid

Chemical Property:

• Vapor Pressure: 2.08E-07mmHg at 25°C
• Melting Point: 143-145°C
• Refractive Index: 1.574
• Boiling Point: 408.6°Cat760mmHg
• PKA: 3.49±0.25(Predicted)
• Flash Point: 215.1°C
• PSA: 57.53000
• Density: 1.206g/cm³
• LogP: 2.53910
• Storage Temp.: -20°C Freezer
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 234.125594432
• Heavy Atom Count: 17
• Complexity: 265

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)C(C2=CC=CC=C2)(C(=O)O)O
• Isomeric SMILES: C1CCC(CC1)[C@](C2=CC=CC=C2)(C(=O)O)O
• Uses: (S)-2-Cyclohexyl-2-hydroxy-phenylacetic Acid (cas# 20585-34-6) is a compound useful in organic synthesis.

Technology Process of (s)-2-Cyclohexyl-2-phenylglycolic acid

There total 86 articles about (s)-2-Cyclohexyl-2-phenylglycolic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

2-(2'-cyclohexen-1'-yl)-2-hydroxy-2-phenylacetic acid (424792-60-9) → cyclohexylmandelic acid (4335-77-7,20585-34-6,20585-39-1,50896-04-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 25 - 30 ℃; for 13h; under 1545.15 Torr;

Reference yield: 97.0%

ethyl 2-cyclohexyl-2-hydroxy-2-phenylacetate (31197-69-0) → cyclohexylmandelic acid (4335-77-7,20585-34-6,20585-39-1,50896-04-3)

Guidance literature:

With sodium hydroxide; water; In methanol; at 80 ℃; for 3.5h;

Reference yield: 90.0%

(+/-)-1-cyclohexyl-1-hydroxy-1-phenylacetonitrile (479353-91-8) → cyclohexylmandelic acid (4335-77-7,20585-34-6,20585-39-1,50896-04-3)

Guidance literature:

With water; enantioselective reaction; Catalytic behavior; Enzymatic reaction;

upstream raw materials:

ethyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Benzilic acid

S-(+)-phenyl-2 cyclohexyl-2 hydroxy-2 acetate de methyle

(S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylacetaldehyde

Downstream raw materials:

cyclohexyl-hydroxy-phenyl-acetic acid-(2-piperidino-ethyl ester)

demethyloxyphenonium

cyclohexylidene-phenyl-acetic acid

dicyclohexyl-hydroxy-acetic acid