methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate

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Chemical Name:methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate
CAS No.:884872-57-5
Molecular Formula:C₂₇H₁₉ClFN₃O₃S
Molecular Weight:519.984
Hs Code.:

Synonyms:methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate

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Chemical Property of methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate

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Technology Process of methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate

There total 1 articles about methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 884872-21-3
7-bromo-N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}[1]benzothieno[2,3-d]pyrimidin-4-amine

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 884872-57-5
methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate

Guidance literature:: With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In ethanol; at 100 ℃; for 0.5h; Microwave;

Reference yield: 86.0%

: 5308-25-8
4-ethylpiperazine

: 884872-57-5
methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate

: N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-7-[(1E)-3-(4-ethylpiperazin-1-yl)-3-oxoprop-1-en-1-yl][1]benzothieno[2,3-d]pyrimidin-4-amine

Guidance literature:: 4-ethylpiperazine; With trimethylaluminum; In hexane; toluene; at 0 ℃; for 0.25h;

methyl (2E)-3-[4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)benzothieno[2,3-d]pyrimidin-7-yl]acrylate; In n-heptane; toluene; at 100 ℃; for 16h;