ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate

Base Information

Chemical Name:ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate
CAS No.:121659-69-6
Molecular Formula:C₂₇H₂₈FNO₄
Molecular Weight:449.522
Hs Code.:

Synonyms:ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate

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Chemical Property of ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate

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Technology Process of ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate

There total 9 articles about ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121659-65-2
4-(4'-fluorophenyl)-3-hydroxymethyl-2-(1'-methylethyl)-quinoline

: 121659-69-6
ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridinium chlorochromate; sodium acetate / CH₂Cl₂ / 20 °C

2: aq. NaOH; trioctylmethylammonium chloride / toluene / 20 °C

3: diisobutylaluminum hydride / toluene / -15 °C

4: NaH; n-BuLi / tetrahydrofuran; hexane / -10 °C

With sodium hydroxide; n-butyllithium; sodium acetate; Aliquat 336; sodium hydride; diisobutylaluminium hydride; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; toluene; 2: Emmons-Horner coupling;
DOI:10.1016/S0968-0896(01)00198-5

Reference yield:

: 121659-66-3
4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinecarboxaldehyde

: 121659-69-6
ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaOH; trioctylmethylammonium chloride / toluene / 20 °C

2: diisobutylaluminum hydride / toluene / -15 °C

3: NaH; n-BuLi / tetrahydrofuran; hexane / -10 °C

With sodium hydroxide; n-butyllithium; Aliquat 336; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene; 1: Emmons-Horner coupling;
DOI:10.1016/S0968-0896(01)00198-5

Reference yield:

: 141-97-9
ethyl acetoacetate

: 121659-68-5
(E)-3-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-2-propenal

: 121659-69-6
ethyl (E)-7-<4-(4-fluorophenyl)-2-(1-methylethyl)-3-quinolinyl>-5-hydroxy-3-oxo-6-heptenoate

Guidance literature:: With n-butyllithium; sodium hydride; Yield given. Multistep reaction; 1.) THF, 0 deg C, 2.) hexane, -78 deg C, 1 h;
DOI:10.1021/jm00105a057