2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid

Base Information

• Chemical Name: 2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid
• CAS No.: 1262837-18-2
• Molecular Formula: C₂₁H₂₅NO₂
• Molecular Weight: 323.435
• Mol file: 1262837-18-2.mol

Synonyms:2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid

Chemical Property of 2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid

There total 3 articles about 2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

H-Gpn-OH (60142-96-3) + methyl 2-naphthyl ketone (93-08-3) → 2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid (1262837-18-2)

Guidance literature:

With sulfuric acid; In ethanol; at 20 ℃;

DOI:10.1007/s00044-010-9498-8

Reference yield:

[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid (99189-60-3) → 2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid (1262837-18-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hypobromide; sodium hydroxide / 15 h / 55 °C

2: sulfuric acid / ethanol / 20 °C

With sodium hypobromide; sulfuric acid; sodium hydroxide; In ethanol; 1: Hofmann rearrangement;

DOI:10.1007/s00044-010-9498-8

Reference yield:

1,1-cyclohexanediacetic acid anhydride (1010-26-0) → 2-(1-((1-(naphthalen-2-yl)ethylideneamino)methyl)cyclohexyl)acetic acid (1262837-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia / water / 2 h / 5 °C

2: sodium hypobromide; sodium hydroxide / 15 h / 55 °C

3: sulfuric acid / ethanol / 20 °C

With sodium hypobromide; sulfuric acid; ammonia; sodium hydroxide; In ethanol; water; 2: Hofmann rearrangement;

DOI:10.1007/s00044-010-9498-8

upstream raw materials:

H-Gpn-OH

methyl 2-naphthyl ketone

[1-(2-amino-2-oxoethyl)cyclohexyl]acetic acid

1,1-cyclohexanediacetic acid anhydride