2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

Base Information

• Chemical Name: 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide
• CAS No.: 1026090-28-7
• Molecular Formula: C₂₈H₂₆F₄N₄O₄S
• Molecular Weight: 590.598
• Mol file: 1026090-28-7.mol

Synonyms:2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

Chemical Property of 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide

There total 10 articles about 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2'-tert-butylaminosulfonyl-3-fluoro-[1,1']-biphen-4-yl)amine (209919-51-7) + 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride (218632-09-8) → 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide (1026090-28-7)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 ℃;

DOI:10.1021/jm030212h

Reference yield:

1,1,1-Trifluoro-2,4-pentanedione (367-57-7) → 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide (1026090-28-7)

Guidance literature:

Multi-step reaction with 7 steps

1: 84 percent / AcOH / 2-methoxy-ethanol / 18 h / Heating

2: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 18 h / Heating; irradiation

3: 18-crown-6 / acetonitrile / 18 h / 20 °C

4: 16.43 g / IR₄₀₀(OH^-) resin / methanol / 3 h / 20 °C

5: 3.03 g / sodium periodate; ruthenium(III) chloride / acetonitrile / 18 h / 20 °C

6: oxalyl chloride; DMF / CH₂Cl₂ / 4 h / 0 °C

7: pyridine; DMAP / CH₂Cl₂ / 0 °C

With pyridine; dmap; ruthenium trichloride; sodium periodate; N-Bromosuccinimide; oxalyl dichloride; 18-crown-6 ether; IR₄₀₀(OH^-) resin; acetic acid; N,N-dimethyl-formamide; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; 2-methoxy-ethanol; acetonitrile;

DOI:10.1021/jm030212h

Reference yield:

4-bromo-2-fluoroaniline (367-24-8) → 2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-3-fluoro-biphenyl-4-yl)-amide (1026090-28-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; H₂O / 18 h / Heating

2: pyridine; DMAP / CH₂Cl₂ / 0 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; dichloromethane; water;

DOI:10.1021/jm030212h

upstream raw materials:

(2'-tert-butylaminosulfonyl-3-fluoro-[1,1']-biphen-4-yl)amine

2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

1,1,1-Trifluoro-2,4-pentanedione

4-bromo-2-fluoroaniline