(2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Base Information

Chemical Name:(2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine
CAS No.:264128-08-7
Molecular Formula:C₃₃H₃₂O₅S
Molecular Weight:540.68
Hs Code.:

Synonyms:(2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine

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Chemical Property of (2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine

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Technology Process of (2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine

There total 6 articles about (2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100-44-7
benzyl chloride

: 264128-07-6
(2S,4aS,6S,7R,8S,8aR)-2-Phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol

: 264128-08-7
(2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(99)02209-1

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 264128-08-7
(2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 2 steps

1: TsOH / dimethylformamide / 70 °C

2: 95 percent / NBu₄I; NaH / tetrahydrofuran

With tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Cyclization / 2: Alkylation;
DOI:10.1016/S0040-4039(99)02209-1

Reference yield:

: 108-98-5
thiophenol

: 264128-08-7
(2S,4aS,6S,7R,8R,8aS)-7,8-Bis-benzyloxy-2-phenyl-6-phenylsulfanyl-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / BF₃*OEt₂ / CH₂Cl₂ / 20 °C

2: NaOMe / methanol

3: TsOH / dimethylformamide / 70 °C

4: 95 percent / NBu₄I; NaH / tetrahydrofuran

With boron trifluoride diethyl etherate; sodium methylate; tetra-(n-butyl)ammonium iodide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Deacetylation / 3: Cyclization / 4: Alkylation;
DOI:10.1016/S0040-4039(99)02209-1