(1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid

Base Information

Chemical Name:(1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid
CAS No.:1352994-77-4
Molecular Formula:C₂₂H₂₂BNO₆
Molecular Weight:407.231
Hs Code.:

Synonyms:(1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid

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Chemical Property of (1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid

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Technology Process of (1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid

There total 6 articles about (1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1429254-28-3
C₃₂H₃₆BNO₆

: 1352994-77-4
(1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid

Guidance literature:: With hydrogenchloride; phenylboronic acid; In hexane; water; acetonitrile; for 0.5h; Inert atmosphere;
DOI:10.1021/jm301490d

Reference yield: 87.0%

: C₃₆H₄₄BNO₆

: 1352994-77-4
(1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid

Guidance literature:: C₃₆H₄₄BNO₆; With methoxybenzene; trifluoroacetic acid; In dichloromethane; for 2h; Inert atmosphere;

With hydrogenchloride; phenylboronic acid; In hexane; water; acetonitrile; Inert atmosphere;
DOI:10.1002/pro.612

Reference yield:

: 69038-74-0
tert-butyl 3-bromobenzoate

: 1352994-77-4
(1R)-1-[(2-ethoxynaphthalene-1-carbonyl)amino]-2-(3-carboxyphenyl)ethaneboronic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -100 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -100 °C / Inert atmosphere

2.2: -100 °C / Inert atmosphere

3.1: tetrahydrofuran / -78 °C / Inert atmosphere

4.1: 2-ethoxy-1-naphthaloic acid / tetrahydrofuran / -78 °C / Inert atmosphere

5.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

5.2: Inert atmosphere

With n-butyllithium; 2-ethoxy-1-naphthaloic acid; methoxybenzene; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/pro.612