4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one

Base Information

Chemical Name:4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one
CAS No.:668476-66-2
Molecular Formula:C₁₈H₁₈ClN₃O
Molecular Weight:327.813
Hs Code.:

4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1<i>H</i>-1,3,8-triaza-cyclohepta[<i>e</i>]inden-2-one

Synonyms:4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one

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Chemical Property of 4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one

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Technology Process of 4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one

There total 7 articles about 4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 668476-53-7
8-chloro-2,3,4,5-tetrahydro-3-methyl-5(R)-phenyl-1H-3-benzazepin-6,7-diamine

: 668476-66-2
4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jm030614p

Reference yield:

: 73445-63-3,84384-04-3,87075-17-0,95191-55-2
SCH 23390

: 668476-66-2
4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / HNO₃; HCOOH / 20 °C

2: 3.89 g / K₂CO₃ / acetone / 70 h / Heating

3: 1.7 g / NaOH / dimethylformamide / 2 h / 20 °C

4: 100 percent / aq. HCl / dioxane / 2 h / Heating

5: 100 percent / Fe; aq. HCl / 1 h / Heating

6: 75 percent / DMAP / acetonitrile / 1 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; formic acid; nitric acid; iron; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; acetone; acetonitrile; 3: Smiles rearrangement;
DOI:10.1021/jm030614p

Reference yield:

: 668476-52-6
8-chloro-2,3,4,5-tetrahydro-3-methyl-6-nitro-5(R)-phenyl-1H-3-benzazepin-7-amine

: 668476-66-2
4-chloro-8-methyl-10-phenyl-3,6,7,8,9,10-hexahydro-1H-1,3,8-triaza-cyclohepta[e]inden-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Fe; aq. HCl / 1 h / Heating

2: 75 percent / DMAP / acetonitrile / 1 h / 20 °C

With hydrogenchloride; dmap; iron; In acetonitrile;
DOI:10.1021/jm030614p