isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

Base Information

Chemical Name:isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester
CAS No.:210300-18-8
Molecular Formula:C₁₉H₂₅NO₆
Molecular Weight:363.411
Hs Code.:

Synonyms:isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

Suppliers and Price of isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

There total 12 articles about isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 215798-16-6
isobutyric acid (3R,6S,7R,8R)-8-benzyl-3-tert-butoxycarbonylamino-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

: 210300-18-8
isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1016/S0040-4020(98)00777-7

Reference yield:

: 96837-44-4
(R)-4-isopropyl-3-(3-phenylpropanoyl)oxazolidin-2-one

: 210300-18-8
isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

Guidance literature:: Multi-step reaction with 11 steps

2: aq. H₂O₂, LiOH / 12 h / 25 °C

3: 89 percent / triphenylphosphine, DIAD / tetrahydrofuran / 0.67 h / 25 °C

4: 99 percent / imidazole / dimethylformamide / 17 h / 60 °C

5: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 0.5 h / 25 °C

6: DMAP, EDCI / CH₂Cl₂ / 2 h / -10 °C

7: H₂ / Pd(OH)2 / ethanol / 24 h / 25 °C / 3040 Torr

8: Ph₃P, DIAD / CH₂Cl₂ / 24 h / 25 °C

9: 100 percent / HF, pyridine / tetrahydrofuran / 72 h / Ambient temperature

10: 90 percent / pyridine / 5.5 h / 0 °C

11: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 25 °C

With pyridine; 1H-imidazole; dmap; lithium hydroxide; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)00777-7

Reference yield:

: 645-45-4
hydrocinnamic acid chloride

: 210300-18-8
isobutyric acid (3R,6S,7R,8R)-3-amino-8-benzyl-6-methyl-4,9-dioxo-[1,5]dioxonane-7-yl ester

Guidance literature:: Multi-step reaction with 12 steps

1: 78 percent / n-butyllithium / tetrahydrofuran / 3 h / -78 °C

3: aq. H₂O₂, LiOH / 12 h / 25 °C

4: 89 percent / triphenylphosphine, DIAD / tetrahydrofuran / 0.67 h / 25 °C

5: 99 percent / imidazole / dimethylformamide / 17 h / 60 °C

6: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 0.5 h / 25 °C

7: DMAP, EDCI / CH₂Cl₂ / 2 h / -10 °C

8: H₂ / Pd(OH)2 / ethanol / 24 h / 25 °C / 3040 Torr

9: Ph₃P, DIAD / CH₂Cl₂ / 24 h / 25 °C

10: 100 percent / HF, pyridine / tetrahydrofuran / 72 h / Ambient temperature

11: 90 percent / pyridine / 5.5 h / 0 °C

12: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 25 °C

With pyridine; 1H-imidazole; dmap; lithium hydroxide; n-butyllithium; di-isopropyl azodicarboxylate; hydrogen fluoride; hydrogen; dihydrogen peroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; pyridine; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(98)00777-7