2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol

Base Information

Chemical Name:2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol
CAS No.:1616405-97-0
Molecular Formula:C₂₀H₂₂ClF₃N₆O
Molecular Weight:454.882
Hs Code.:

Synonyms:2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol

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Chemical Property of 2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol

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Technology Process of 2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol

There total 7 articles about 2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.2%

: 1616406-11-1
2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-one

: 1616405-97-0
2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm500535j

Reference yield:

: 126824-11-1
2-amino-6-(4-methylpiperazin-1-yl)-3-nitropyridine

: 1616405-97-0
2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 1 h / Inert atmosphere

2: methanol; water / 16 h / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

4: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm500535j

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1616405-97-0
2-(2-amino-5-(4-methylpiperazin-1-yl)-3H-imidazo[4,5-b]pyridin-3-yl)-1-(2-chloro-4-(trifluoromethyl)phenyl)ethan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 1 h / Inert atmosphere

3: methanol; water / 16 h / 0 - 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 150 °C / Inert atmosphere; Microwave irradiation

5: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm500535j