Technology Process of methyl(2-fluoro-4-{2-[(1S,2R)-2-{1-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)acetate
There total 12 articles about methyl(2-fluoro-4-{2-[(1S,2R)-2-{1-[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]piperidin-4-yl}cyclopropyl]ethoxy}phenyl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sulfuric acid
2: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C
With
di-tert-butyl-diazodicarboxylate;
sulfuric acid;
In
dichloromethane;
- Guidance literature:
-
With
di-tert-butyl-diazodicarboxylate;
In
dichloromethane;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.08 h / -78 °C
1.2: 1 h / -78 °C
2.1: hydrogen; quinoline / Lindlars catalyst / ethyl acetate / 0.67 h
3.1: diethylzinc / dichloromethane; diethyl ether / 0.17 h / -20 °C / Inert atmosphere
3.2: 0.17 h
3.3: 24 h / 0 °C
4.1: hydrogen / palladium(II) hydroxide / ethyl acetate; ethanol / 2585.81 Torr
4.2: 0 °C
4.3: 0.5 h / 20 °C
5.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C
6.1: sodium hydrogencarbonate / dichloromethane; water / 0.08 h / 0 °C
6.2: 1.5 h / 0 - 20 °C
7.1: ethyl acetate; tetrahydrofuran
7.2: 2 h / 70 °C / Inert atmosphere
7.3: 80 °C
8.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C
With
quinoline; hydrogenchloride; n-butyllithium; di-tert-butyl-diazodicarboxylate; hydrogen; diethylzinc; sodium hydrogencarbonate;
palladium(II) hydroxide;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; water; ethyl acetate;