1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine

Base Information

Chemical Name:1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine
CAS No.:121417-06-9
Molecular Formula:C₃₁H₂₇N₃O₅
Molecular Weight:521.572
Hs Code.:

Synonyms:1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine

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Chemical Property of 1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine

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Technology Process of 1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine

There total 7 articles about 1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 158774-88-0
1-<5-O-(4-monomethoxytrityl)-3-deoxy-3-C-nitromethyl-β-D-xylo-pentofuranosyl>thymine

: 121417-06-9
1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine

Guidance literature:: With phenoxy-thiocarbonyl chloride; 4,4-N-dimethylaminopyridine; In acetonitrile; for 6h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86711-9

Reference yield:

: Methanesulfonic acid (2R,5R)-3-cyano-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 121417-06-9
1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine

Guidance literature:: With TEA; In pyridine; for 5h; Yield given; Heating;
DOI:10.1016/0040-4020(89)80117-6

Reference yield:

: 1-<5-O-(4-monomethoxytrityl)-2-(R)-O-t-butyldimethylsilyl-3-deoxy-3-C-nitromethyl-β-D-pentofuranosyl>thymine

: 121417-06-9
1-<5'-O-(4-monomethoxytrityl)-2',3'-dideoxy-3'-C-cyano-β-D-glycero-pento-2'-enofuranosyl>thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 20 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

2: 11 percent / phenoxythiocarbonyl chloride, 4,4-N-dimethylaminopyridine / acetonitrile / 6 h / Ambient temperature

With phenoxy-thiocarbonyl chloride; 4,4-N-dimethylaminopyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran; acetonitrile;
DOI:10.1016/S0040-4020(01)86711-9