(2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

Base Information

Chemical Name:(2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate
CAS No.:737830-23-8
Molecular Formula:C₂₄H₂₁NO₁₂
Molecular Weight:515.43
Hs Code.:

Synonyms:(2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

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Chemical Property of (2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

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Technology Process of (2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

There total 6 articles about (2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 737830-19-2
di-tert-butyl (2S,3S)-3-benzyloxy-N-{[7-(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

: 737830-23-8
(2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.bmc.2004.04.011

Reference yield:

: 737830-18-1
di-tert-butyl (2S,3S)-3-benzyloxyaspartate

: 737830-23-8
(2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 mg / i-Pr₂NEt / CH₂Cl₂ / 0.17 h

2: 42 percent / TFA / CH₂Cl₂ / 5 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2004.04.011

Reference yield:

: di-tert-butyl (2S,3S)-3-benzyloxy-N-tert-butoxycarbonylaspartate

: 737830-23-8
(2S,3S)-3-benzyloxy-N-{[7-(carboxymethoxy)coumarin-4-yl-methoxy]carbonyl}aspartate

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / TFA / CH₂Cl₂ / 1 h / 0 °C

2: 84 mg / i-Pr₂NEt / CH₂Cl₂ / 0.17 h

3: 42 percent / TFA / CH₂Cl₂ / 5 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2004.04.011