Technology Process of (6-(benzyloxy)-5-(hydroxymethyl)pyrimidin-4-yl)(pyridin-3-yl)methanol
There total 3 articles about (6-(benzyloxy)-5-(hydroxymethyl)pyrimidin-4-yl)(pyridin-3-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(4-(benzyloxy)-6-iodopyrimidin-5-yl)methanol;
With
methylmagnesium bromide;
In
tetrahydrofuran; diethyl ether;
at -50 ℃;
for 0.333333h;
With
TurboGrignard;
In
tetrahydrofuran; diethyl ether;
at -50 - 0 ℃;
3-pyridinecarboxaldehyde;
Further stages;
DOI:10.1016/j.tet.2012.04.033
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 0 - 20 °C
2.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.33 h / -50 °C
2.2: -50 - 0 °C
With
methylmagnesium bromide; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; diethyl ether;
DOI:10.1016/j.tet.2012.04.033
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen iodide / water / 1 h / 20 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C
3.1: sodium
3.2: 14 h / 0 - 20 °C
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 15 h / 0 - 20 °C
5.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.33 h / -50 °C
5.2: -50 - 0 °C
With
1H-imidazole; methylmagnesium bromide; tetrabutyl ammonium fluoride; hydrogen iodide; sodium;
In
tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.04.033
