trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Base Information

Chemical Name:trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine
CAS No.:1357001-64-9
Molecular Formula:C₂₄H₂₈FN₃
Molecular Weight:377.505
Hs Code.:

Synonyms:trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Chemical Property of trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Technology Process of trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

There total 2 articles about trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 61-54-1
tryptamine

: 65618-76-0
4-(dimethylamino)-4-(4-fluorophenyl)cyclohexan-1-one

: 1357001-64-9
trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

: 1357001-63-8
cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: tryptamine; 4-(dimethylamino)-4-(4-fluorophenyl)cyclohexan-1-one; In methanol; for 18h; Inert atmosphere;

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

With sodium hydroxide; In 1,2-dichloro-ethane; at 20 ℃; pH=11; cooling with ice;

Reference yield:

: 4-(p-fluorophenyl)-4-dimethylaminocyclohexanone, ethylene ketal hydrochloride

: 1357001-64-9
trans-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)-spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

: 1357001-63-8
cis-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(4-fluorophenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: methanol / 18 h / Inert atmosphere

2.2: 2 h / 20 °C

2.3: 20 °C / pH 11 / cooling with ice

With hydrogenchloride; water; In methanol;