2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine
CAS No.:415902-95-3
Molecular Formula:C₂₆H₂₉N₅O₃S
Molecular Weight:491.614
Hs Code.:

Synonyms:2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

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Chemical Property of 2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

Chemical Property:

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Technology Process of 2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

There total 12 articles about 2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 415907-63-0
2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylamine

: 4083-64-1
Tosyl isocyanate

: 415902-95-3
2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 415907-58-3
2-{4-[(3-amino-4,6-dimethyl-2-pyridinyl)amino]phenyl}ethanol

: 415902-95-3
2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 2 h / 0 °C / Heating / reflux

2: lithium hydroxide; water / 3 h / 20 °C

3: thionyl chloride / toluene / 3 h / 80 °C

4: sodium azide; potassium iodide / N,N-dimethyl-formamide / 100 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 4 h

6: dichloromethane / 3 h / 20 °C

With lithium hydroxide; thionyl chloride; sodium azide; water; hydrogen; potassium iodide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 415907-60-7
2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethanol

: 415902-95-3
2-ethyl-5,7-dimethyl-3-(4-{2-[({[(4-methylphenyl)sulfonyl]amino}carbonyl)amino]ethyl}phenyl)-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / toluene / 3 h / 80 °C

2: sodium azide; potassium iodide / N,N-dimethyl-formamide / 100 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 4 h

4: dichloromethane / 3 h / 20 °C

With thionyl chloride; sodium azide; hydrogen; potassium iodide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;