Technology Process of trans-3-(benzoyloxy)-6-(α-furyl)-2-<(1-phenylseleno)ethyl>-2,3-dihydro-4H-pyran-4-one
There total 6 articles about trans-3-(benzoyloxy)-6-(α-furyl)-2-<(1-phenylseleno)ethyl>-2,3-dihydro-4H-pyran-4-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / thionyl chloride / 3 h / Heating
2: 1.) hexamethyldisilazane, N-butyllithium; 2.) HCl (2N) / 1.) THF, 0 deg C, 1 h; 2.) toluene, -78 deg C, 35 min
3: 100 percent / diethyl ether / 0.67 h / 0 °C
4: 100 percent / triethylamine (Et3N) / diethyl ether / 1.) -78 deg C, 10 min; 2.) room temp., 0.5 h
5: 2.) trifluoroacetic acid (TFA) / 1.) boron trifluoride etherate (BF3*Et2O) / 1.) dichloromethane, -78 deg C, 20 min; 2.) 1 h
With
hydrogenchloride; n-butyllithium; thionyl chloride; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid;
boron trifluoride diethyl etherate;
In
diethyl ether;
DOI:10.1021/ja00291a030
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) hexamethyldisilazane, N-butyllithium; 2.) HCl (2N) / 1.) THF, 0 deg C, 1 h; 2.) toluene, -78 deg C, 35 min
2: 100 percent / diethyl ether / 0.67 h / 0 °C
3: 100 percent / triethylamine (Et3N) / diethyl ether / 1.) -78 deg C, 10 min; 2.) room temp., 0.5 h
4: 2.) trifluoroacetic acid (TFA) / 1.) boron trifluoride etherate (BF3*Et2O) / 1.) dichloromethane, -78 deg C, 20 min; 2.) 1 h
With
hydrogenchloride; n-butyllithium; triethylamine; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid;
boron trifluoride diethyl etherate;
In
diethyl ether;
DOI:10.1021/ja00291a030
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / diethyl ether / 0.67 h / 0 °C
2: 100 percent / triethylamine (Et3N) / diethyl ether / 1.) -78 deg C, 10 min; 2.) room temp., 0.5 h
3: 2.) trifluoroacetic acid (TFA) / 1.) boron trifluoride etherate (BF3*Et2O) / 1.) dichloromethane, -78 deg C, 20 min; 2.) 1 h
With
triethylamine; trifluoroacetic acid;
boron trifluoride diethyl etherate;
In
diethyl ether;
DOI:10.1021/ja00291a030
