3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate

Base Information

Chemical Name:3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate
CAS No.:136667-92-0
Molecular Formula:C₂₇H₃₁NO₆SSi
Molecular Weight:525.698
Hs Code.:

Synonyms:3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate

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Chemical Property of 3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate

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Technology Process of 3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate

There total 3 articles about 3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 136667-89-5
3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-amino-4-methylthiophene-3,5-dicarboxylate

: 501-53-1,94274-21-2
benzyl chloroformate

: 136667-92-0
3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 12h;
DOI:10.1021/jo00025a044

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 136667-92-0
3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent Turnov_. / NaOAc

2: 52 percent / elemental sulfur (S₈), Et₂NH / 2-methyl-propan-2-ol / 22 h / 70 °C

3: 48 percent / 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 12 h

With sulfur; dmap; sodium acetate; diethylamine; triethylamine; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00025a044

Reference yield:

: 17165-45-6
2-(trimethylsilyl)ethyl acetoacetate

: 136667-92-0
3-benzyl 5-<2-(trimethylsilyl)ethyl> 2-<<(phenylmethoxy)carbonyl>amino>-4-methylthiophene-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / elemental sulfur (S₈), Et₂NH / 2-methyl-propan-2-ol / 22 h / 70 °C

2: 48 percent / 4-(dimethylamino)pyridine, Et₃N / CH₂Cl₂ / 12 h

With sulfur; dmap; diethylamine; triethylamine; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/jo00025a044