N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide

Base Information

Chemical Name:N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide
CAS No.:1328624-52-7
Molecular Formula:C₂₅H₂₃ClN₆O₅S
Molecular Weight:555.014
Hs Code.:

Synonyms:N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide

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Chemical Property of N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide

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Technology Process of N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide

There total 5 articles about N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1328624-29-8
5-(3-(aminomethyl)isooxazol-5-yl)-N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)pyrimidin-4-amine

: 72707-66-5
2-(bromomethyl)acrylic acid

: 20277-69-4
sodium methansulfinate

: 1328624-52-7
N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide

Guidance literature:: 2-(bromomethyl)acrylic acid; sodium methansulfinate; In methanol; at 70 ℃; for 2h;

5-(3-(aminomethyl)isooxazol-5-yl)-N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)pyrimidin-4-amine; With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 1328624-25-4
N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-5-iodopyrimidin-4-amine

: 1328624-52-7
N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 24 h / 20 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.1: N-chloro-succinimide; pyridine / tetrahydrofuran / 2 h / 70 °C

3.2: 12 h / 70 °C

4.1: hydrazine hydrate / ethanol / 1 h / 70 °C

5.1: methanol / 2 h / 70 °C

5.2: 1 h / 20 °C

With pyridine; N-chloro-succinimide; tetrabutyl ammonium fluoride; hydrazine hydrate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; methanol; ethanol;

Reference yield:

: 1328624-28-7
2-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isooxazol-3-yl)methyl)isoindoline-1,3-dione

: 1328624-52-7
N-((5-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)methyl)-2-(methylsulfonylmethyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / ethanol / 1 h / 70 °C

2.1: methanol / 2 h / 70 °C

2.2: 1 h / 20 °C

With hydrazine hydrate; In methanol; ethanol;