<3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide

Base Information

Chemical Name:<3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide
CAS No.:158268-36-1
Molecular Formula:C₂₃H₂₈F₂N₂O₅
Molecular Weight:450.483
Hs Code.:

Synonyms:<3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide

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Chemical Property of <3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide

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Technology Process of <3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide

There total 1 articles about <3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(1S,2S)-3-Benzylcarbamoyl-1-(4-benzyloxy-benzyl)-3,3-difluoro-2-hydroxy-propyl]-carbamic acid tert-butyl ester

: 158268-36-1
<3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide

Guidance literature:: With formic acid; palladium; In methanol; for 4.25h;
DOI:10.1021/jm00048a004

Reference yield:

: 158268-36-1
<3(S),4(S)>-2,4,5-trideoxy-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,2-difluoro-5-(4-hydroxyphenyl)-N-(phenylmethyl)-L-glycero-pentonamide

: [4-((S)-2-Amino-4-benzylcarbamoyl-4,4-difluoro-3-hydroxy-butyl)-phenoxy]-acetic acid methyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃, KI / acetone / 72 h

2: 2 h

With potassium carbonate; potassium iodide; In acetone;
DOI:10.1021/jm00048a004