(2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Base Information

Chemical Name:(2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone
CAS No.:1456892-06-0
Molecular Formula:C₂₄H₂₃F₃N₄OS
Molecular Weight:472.534
Hs Code.:

Synonyms:(2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

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Chemical Property of (2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

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Technology Process of (2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

There total 10 articles about (2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1456892-35-5
C₁₃H₁₆F₃N₃

: 13743-09-4
2-methyl-5-phenyl-1,3-thiazole-4-carboxylic acid

: 1456892-06-0
(2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Guidance literature:: 2-methyl-5-phenyl-1,3-thiazole-4-carboxylic acid; With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; In 1,4-dioxane; at 25 ℃; for 0.5h;

C₁₃H₁₆F₃N₃; In 1,4-dioxane; at 60 ℃;

Reference yield:

: 128726-44-3
(S)-6-oxo-piperidine-2-carboxylic acid ethyl ester

: 1456892-06-0
(2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Guidance literature:: Multi-step reaction with 10 steps

1.1: dmap / toluene / 20 °C

2.1: lithium triethylborohydride / toluene; tetrahydrofuran / 0.5 h / -50 - -45 °C

2.2: 2.5 h / 20 °C

3.1: diethylzinc / toluene; hexane / 16 h / -30 - -15 °C

4.1: sodium hydroxide; ethanol / 5.5 h / 0 - 20 °C

5.1: diborane / tetrahydrofuran / 2 h / 0 - 20 °C

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 3 h / 0 - 20 °C

7.1: hydrazine hydrate / ethanol / 16 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C

9.1: trifluoroacetic acid / dichloromethane / 20 °C

10.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

10.2: 60 °C

With 4-methyl-morpholine; dmap; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrazine hydrate; ethanol; diethylzinc; lithium triethylborohydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diborane; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 149733-38-0
(S)-6-oxo-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 1456892-06-0
(2-methyl-5-phenylthiazol-4-yl)((1R,3S,6S)-3-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)-2-azabicyclo[4.1.0]heptan-2-yl)methanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium triethylborohydride / toluene; tetrahydrofuran / 0.5 h / -50 - -45 °C

1.2: 2.5 h / 20 °C

2.1: diethylzinc / toluene; hexane / 16 h / -30 - -15 °C

3.1: sodium hydroxide; ethanol / 5.5 h / 0 - 20 °C

4.1: diborane / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 3 h / 0 - 20 °C

6.1: hydrazine hydrate / ethanol / 16 h / 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 120 °C

8.1: trifluoroacetic acid / dichloromethane / 20 °C

9.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 1,4-dioxane / 0.5 h / 25 °C

9.2: 60 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; hydrazine hydrate; ethanol; diethylzinc; lithium triethylborohydride; potassium carbonate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diborane; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;