5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline

Base Information

Chemical Name:5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline
CAS No.:1192829-40-5
Molecular Formula:C₂₁H₁₉N₃O₃
Molecular Weight:361.4
Hs Code.:

Synonyms:5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline

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Chemical Property of 5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline

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Technology Process of 5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline

There total 2 articles about 5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192829-62-1
N-hydroxy-5-isoquinolinecarboximidamide

: 3535-33-9
4-isopropyloxy-3-methoxybenzoic acid

: 1192829-40-5
5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline

Guidance literature:: 4-isopropoxy-3-methoxy-benzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

N-hydroxy-5-isoquinolinecarboximidamide; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 3.5 - 4.5h; Microwave;

Reference yield:

: 27655-41-0
isoquinoline-5-carbonitrile

: 1192829-40-5
5-{5-[4-[(1-methylethyl)oxy]-3-(methyloxy)phenyl]-1,2,4-oxadiazol-3-yl}isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 15 h / 65 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

2.2: 3.5 - 4.5 h / 20 - 140 °C / Microwave

With hydroxylamine hydrochloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide;