4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid

Base Information

• Chemical Name: 4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid
• CAS No.: 861108-93-2
• Molecular Formula: C₃₉H₅₆INO₆
• Molecular Weight: 761.781
• Mol file: 861108-93-2.mol

Synonyms:4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid

Chemical Property of 4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid

There total 5 articles about 4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid dimethyl ester (861108-92-1) → 4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid (861108-93-2)

Guidance literature:

With sodium hydroxide; In methanol; at 0 ℃; for 0.5h;

DOI:10.1021/ja0524088

Reference yield:

4-ethynylpyridine-2,6-dicarboxylic acid dimethyl ester (861108-90-9) → 4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid (861108-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / CuI; i-PrNEt; (Ph₃P)2PdCl₂ / tetrahydrofuran

2: 98 percent / NaOH / methanol / 0.5 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium hydroxide; copper(l) iodide; i-PrNEt; In tetrahydrofuran; methanol;

DOI:10.1021/ja0524088

Reference yield:

4-trimethylsilylethynyl-2,6-pyridinedicarnoxylic acid dimethyl ester (861108-88-5) → 4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid (861108-93-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / KF / methanol / 0.25 h

2: 63 percent / CuI; i-PrNEt; (Ph₃P)2PdCl₂ / tetrahydrofuran

3: 98 percent / NaOH / methanol / 0.5 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; sodium hydroxide; copper(l) iodide; i-PrNEt; In tetrahydrofuran; methanol;

DOI:10.1021/ja0524088

upstream raw materials:

4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid dimethyl ester

4-ethynylpyridine-2,6-dicarboxylic acid dimethyl ester

4-trimethylsilylethynyl-2,6-pyridinedicarnoxylic acid dimethyl ester

4-trifluoromethanesulfonyloxy-pyridine-2,6-dicarboxylic acid dimethyl ester

Downstream raw materials:

4-(2,5-didodecyloxy-4-iodophenylethynyl)-pyridine-2,6-dicarboxylic acid chloride