1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide

Base Information

Chemical Name:1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide
CAS No.:1092374-44-1
Molecular Formula:C₁₉H₁₇F₂N₃O₂S
Molecular Weight:389.426
Hs Code.:

Synonyms:1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide

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Chemical Property of 1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide

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Technology Process of 1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide

There total 5 articles about 1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96-50-4
2-thiazolylamine

: 1092375-64-8
1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid chloride

: 1092374-44-1
1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide

Guidance literature:: With pyridine; In 1,2-dichloro-ethane; at 0 - 40 ℃; Inert atmosphere;

Reference yield:

: 1092375-60-4
4-isobutyryl-1H-pyrrole-2-carboxylic acid methyl ester

: 1092374-44-1
1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 40 - 50 °C

1.2: 18 h / 50 °C

2.1: potassium hydroxide; ethanol; water / 18 h / Heating / reflux

3.1: thionyl chloride / N,N-dimethyl-formamide / 1,1-dichloroethane / 3 - 4 h / 0 - 80 °C

4.1: pyridine / 1,2-dichloro-ethane / 4 - 5 h / 0 - 40 °C

With pyridine; potassium hydroxide; thionyl chloride; ethanol; water; caesium carbonate; N,N-dimethyl-formamide; In 1,1-dichloroethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1092375-61-5
1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid methyl ester

: 1092374-44-1
1-(3,4-difluoro-benzyl)-4-isobutyryl-1H-pyrrole-2-carboxylic acid thiazol-2-ylamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; ethanol; water / 18 h / Heating / reflux

2: thionyl chloride / N,N-dimethyl-formamide / 1,1-dichloroethane / 3 - 4 h / 0 - 80 °C

3: pyridine / 1,2-dichloro-ethane / 4 - 5 h / 0 - 40 °C

With pyridine; potassium hydroxide; thionyl chloride; ethanol; water; N,N-dimethyl-formamide; In 1,1-dichloroethane; 1,2-dichloro-ethane;