2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

Base Information

Chemical Name:2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate
CAS No.:125104-17-8
Molecular Formula:C₁₅H₁₅NO₅
Molecular Weight:289.288
Hs Code.:

Synonyms:2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

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Chemical Property of 2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

Chemical Property:

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Technology Process of 2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

There total 1 articles about 2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125104-17-8
2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

Guidance literature:

Reference yield:

: 125104-17-8
2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

: 125130-50-9
8-<(3,4-dichlorophenyl)acetyl>-7-(1-pyrrolidinylmethyl)-1,4-dithia-8-azaspiro<4.5>decane

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Me₂PhSiH, (Ph₃P)3RhCl, 2.) 40percent aq. HF / 1.) 50 deg C, 3 h, 2.) acetonitrile, RT, 18 h

2: 99 percent / PTSA, 4 Angstroem molecular sieves / benzene / 4 h / Heating

3: 91 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

4: 79 percent / 2 h / 150 °C

5: 43 percent / LiAlH₄ / tetrahydrofuran / 19 h / Heating

6: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 1 h, 2.) acetonitrile, RT, 4 h

7: 67 percent / aq. H₂SO₄ / acetone / 40 h / Heating

8: 51 percent / BF₃*Et₂O / CH₂Cl₂ / 18 h / Ambient temperature

With Wilkinson's catalyst; lithium aluminium tetrahydride; 4 A molecular sieve; sulfuric acid; Dimethylphenylsilane; boron trifluoride diethyl etherate; hydrogen fluoride; hydrogen; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; benzene;
DOI:10.1021/jm00081a009

Reference yield:

: 125104-17-8
2-Methyl 1-(phenylmethyl) 3,4-dihydro-4-oxo-1,2(2H)-pyridinedicarboxylate

: 125104-47-4
1-<(3,4-dichlorophenyl)acetyl>-4-oxo-2-(1-pyrrolidinylmethyl)piperidine hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Me₂PhSiH, (Ph₃P)3RhCl, 2.) 40percent aq. HF / 1.) 50 deg C, 3 h, 2.) acetonitrile, RT, 18 h

2: 99 percent / PTSA, 4 Angstroem molecular sieves / benzene / 4 h / Heating

3: 91 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h

4: 79 percent / 2 h / 150 °C

5: 43 percent / LiAlH₄ / tetrahydrofuran / 19 h / Heating

6: 1.) 1,1'-carbonyldiimidazole / 1.) acetonitrile, RT, 1 h, 2.) acetonitrile, RT, 4 h

7: 67 percent / aq. H₂SO₄ / acetone / 40 h / Heating

8: NaBH₄, Al₂O₃ / ethanol / 1.5 h / Ambient temperature

With aluminum oxide; sodium tetrahydroborate; Wilkinson's catalyst; lithium aluminium tetrahydride; 4 A molecular sieve; sulfuric acid; Dimethylphenylsilane; hydrogen fluoride; hydrogen; toluene-4-sulfonic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; acetone; benzene;
DOI:10.1021/jm00081a009