(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

Base Information

Chemical Name:(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide
CAS No.:499121-08-3
Molecular Formula:C₃₃H₅₂O₅Si₂
Molecular Weight:584.944
Hs Code.:

Synonyms:(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

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Chemical Property of (2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

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Technology Process of (2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

There total 16 articles about (2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 499121-01-6
(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-dihydroxy-4-butanolide

: 499121-08-3
(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

Guidance literature:: In pyridine; at 50 ℃;

Reference yield:

: 499121-00-5
(3S,4S,5R)-5-Benzyl-3-((R)-1-benzyloxy-propyl)-tetrahydro-furan-2,3,4-triol

: 499121-08-3
(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.11 g / N-iodosuccinimide; n-Bu₄NI / CH₂Cl₂ / 72 h / 20 °C

2: 95 percent / pyridine / 12 h / 50 °C

With pyridine; N-iodo-succinimide; tetra-(n-butyl)ammonium iodide; In dichloromethane;
DOI:10.1246/bcsj.77.1703

Reference yield:

: (4R,5S)-4-((R)-1-Benzyloxy-propyl)-5-((R)-1-hydroxy-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde

: 499121-08-3
(2R,3S,4R)-4-benzyl-2-[(1R)-1-(benzyloxy)propyl]-2,3-bis(triethylsiloxy)-4-butanolide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. CF₃CO₂H / 9 h / 20 °C

2: 1.11 g / N-iodosuccinimide; n-Bu₄NI / CH₂Cl₂ / 72 h / 20 °C

3: 95 percent / pyridine / 12 h / 50 °C

With pyridine; N-iodo-succinimide; tetra-(n-butyl)ammonium iodide; trifluoroacetic acid; In dichloromethane;
DOI:10.1246/bcsj.77.1703