3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester

Base Information

• Chemical Name: 3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester
• CAS No.: 1053659-12-3
• Molecular Formula: C₂₀H₁₈O₃
• Molecular Weight: 306.361
• Mol file: 1053659-12-3.mol

Synonyms:3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester

Chemical Property of 3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester

There total 1 articles about 3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Methoxy-2-(2-naphthylmethyl)benzoic Acid (73453-81-3) + dimethyl sulfate (77-78-1) → 3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester (1053659-12-3)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 48h;

DOI:10.1021/ol027315z

Reference yield: 97.0%

3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester (1053659-12-3) → (3-methoxy-2-naphthalen-2-ylmethyl-phenyl)-methanol (1053659-04-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 24h;

DOI:10.1021/ol027315z

Reference yield:

3-methoxy-2-naphthalen-2-ylmethyl-benzoic acid methyl ester (1053659-12-3) → 2-hydroxy-2-(3-methoxy-2-naphthalen-2-ylmethyl-benzyl)-cyclooctanone

Guidance literature:

Multi-step reaction with 3 steps

1.1: 97 percent / lithium aluminum hydride / diethyl ether / 24 h / 20 °C

2.1: 80 percent / phosphorus tribromide / diethyl ether / 3 h

3.1: sodium hydride / dimethylformamide / 0.17 h / 20 °C

3.2: 40 percent / dimethylformamide / 24 h / -15 °C

With lithium aluminium tetrahydride; phosphorus tribromide; sodium hydride; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1021/ol027315z

upstream raw materials:

3-Methoxy-2-(2-naphthylmethyl)benzoic Acid

dimethyl sulfate

Downstream raw materials:

(3-methoxy-2-naphthalen-2-ylmethyl-phenyl)-methanol

2-(2-naphthylmethyl)-3-methoxybenzyl bromide