4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

Base Information

Chemical Name:4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin
CAS No.:1600500-30-8
Molecular Formula:C₃₁H₂₇ClFN₃O₈
Molecular Weight:624.022
Hs Code.:

Synonyms:4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

Suppliers and Price of 4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

Chemical Property:

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Technology Process of 4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

There total 2 articles about 4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85862-85-7
4-azido-2-chloro-1-fluorobenzene

: 4α,β-(4-O-propargyl)podophyllotoxin

: 1600500-29-5
4α-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

: 1600500-30-8
4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

Guidance literature:: With copper(ll) sulfate pentahydrate; L-ascorbic acid sodium; In water; tert-butyl alcohol; at 70 ℃; for 1h;
DOI:10.1016/j.ejmech.2014.02.030

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 1600500-29-5
4α-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

: 1600500-30-8
4β-[O-methyl(meta-chloro-para-fluorophenyl-1,2,3-triazol-4yl)]podophyllotoxin

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 0.5 h / 0 - 5 °C

1.2: 1 h / 0 - 5 °C

2.1: L-ascorbic acid sodium; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 1 h / 70 °C

With hydrogenchloride; copper(ll) sulfate pentahydrate; L-ascorbic acid sodium; In water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2014.02.030