methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

Base Information

Chemical Name:methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate
CAS No.:535967-29-4
Molecular Formula:C₂₂H₂₀N₂O₆
Molecular Weight:408.411
Hs Code.:

Synonyms:methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

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Chemical Property of methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

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Technology Process of methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

There total 9 articles about methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2RS,4RS)-2-benzyloxycarbonylamino-4-carboxy-4-(3-indolylmethyl)-γ-butyrolactone

: 535967-29-4
methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

: 535967-30-7
(2R,4R)-2-benzyloxycarbonylamino-4-carboxy-4-(3-indolylmethyl)-γ-butyrolactone

Guidance literature:: With CHIRALPAK AS; In ethanol; hexane; acetic acid; at 40 ℃; Overall yield = 70.7 %;
DOI:10.1248/cpb.c16-00286

Reference yield:

: C₂₃H₂₂N₂O₆

: 535967-29-4
methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

: 1135416-05-5
methyl (2R,4R)-2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: C₂₃H₂₂N₂O₆; With water; In acetonitrile; at 20 ℃; for 19h; pH=7.5; Phosphate buffer;

With hydrogenchloride; water; In dichloromethane; pH=2; Product distribution / selectivity;

Reference yield:

: methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

: 535967-29-4
methyl 2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

: 1135416-05-5
methyl (2R,4R)-2-((1H-indol-3-yl)methyl)-4-(benzyloxycarbonylamino)-5-oxotetrahydrofuran-2-carboxylate

Guidance literature:: With protease from Bacillus lichenformis ChiroCLEC-BL; In acetonitrile; at 22 ℃; for 19h; pH=7.5; enantioselective reaction; aq. phosphate buffer; Large scale reaction; Enzymatic reaction;
DOI:10.1021/op1001947