Pyrimido[1,2-a]benzimidazol-2(1H)-one, 3,4-dihydro- (8CI,9CI)

Base Information

• Chemical Name: Pyrimido[1,2-a]benzimidazol-2(1H)-one, 3,4-dihydro- (8CI,9CI)
• CAS No.: 24811-77-6
• Molecular Formula: C10H9 N3 O
• Molecular Weight: 187.19796
• Hs Code.: 2933990090
• Mol file: 24811-77-6.mol

Synonyms:3,4-Dihydropyrimidino[1,2-a]benzimidazol-2(1H)-one

Chemical Property of Pyrimido[1,2-a]benzimidazol-2(1H)-one, 3,4-dihydro- (8CI,9CI)

Chemical Property:

• PSA: 50.41000
• LogP: 1.46360

Purity/Quality:

99% ^*data from raw suppliers

3,4-dihydro-Pyrimido[1,2-a]benzimidazol-2(1H)-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimido[1,2-a]benzimidazol-2(1H)-one, 3,4-dihydro- (8CI,9CI)

There total 12 articles about Pyrimido[1,2-a]benzimidazol-2(1H)-one, 3,4-dihydro- (8CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

bromocyane (506-68-3) + methyl 3-((2-aminophenyl)amino)propanoate (1270914-58-3) → 3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-2(1H)-one (24811-77-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 100 ℃; for 14h; Temperature;

Reference yield: 85.0%

3-azidopropanoic acid (18523-47-2,79583-67-8) + 1H-benzoimidazol-2-ylamine hydrochloride (26893-41-4,70665-64-4) → 2,10-dihydropyrimido[1,2-a]benzimidazol-4(3H)-one (24811-77-6)

Guidance literature:

3-azidopropanoic acid; With triethylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 25 ℃; for 0.0833333h;

1H-benzoimidazol-2-ylamine hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 5h; Inert atmosphere; Darkness;

DOI:10.1021/jo401738f

Reference yield: 73.0%

1H-benzimidazol-2-amine (934-32-7) + ethyl acrylate (140-88-5,9003-32-1) → 3,4-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-2(1H)-one (24811-77-6)

Guidance literature:

In diethylene glycol dimethyl ether; Heating;

DOI:10.1002/(SICI)1521-4184(199807)331:7/8<249::AID-ARDP249>3.0.CO;2-B

upstream raw materials:

2-(3-chloropropionylamino)benzimidazole

1H-benzimidazol-2-amine

ethyl acrylate

1,2-diamino-benzene