(-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate

Base Information

• Chemical Name: (-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate
• CAS No.: 136032-07-0
• Molecular Formula: C₂₀H₂₀O₃
• Molecular Weight: 308.377
• Mol file: 136032-07-0.mol

Synonyms:(-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate

Chemical Property of (-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate

There total 2 articles about (-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(1R,2S)-trans-2-phenylcyclohexanol (98919-68-7) + Benzoylformic acid (611-73-4) → (-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate (136032-07-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1021/jo00119a023

Reference yield:

phenylglyoxal hydrate (1074-12-0) + (1R,2S)-trans-2-phenylcyclohexanol (98919-68-7) → (-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate (136032-07-0)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; Heating;

DOI:10.1016/S0040-4039(00)92724-2

Reference yield: 97.0%

(-)-<(1R,2S)-2-phenylcyclohex-1-yl>phenylglyoxalate (136032-07-0) + C9H19O(1-)*C6H15Al*Li(1+) → (R)-2-Hydroxy-2-phenyl-butyric acid (1R,2S)-2-phenyl-cyclohexyl ester (142798-12-7)

Guidance literature:

In hexane; cyclohexane; at 0 ℃;

DOI:10.1016/S0040-4039(99)01415-X

upstream raw materials:

phenylglyoxal hydrate

(1R,2S)-trans-2-phenylcyclohexanol

Benzoylformic acid

Downstream raw materials:

2-Hydroxy-2-phenyl-propionic acid (1R,2S)-2-phenyl-cyclohexyl ester

(R)-2-Hydroxy-2-phenyl-butyric acid (1R,2S)-2-phenyl-cyclohexyl ester

(S)-2-Hydroxy-2-phenyl-butyric acid (1R,2S)-2-phenyl-cyclohexyl ester

Hydroxy-phenyl-acetic acid (1R,2S)-2-phenyl-cyclohexyl ester