5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione

Base Information

• Chemical Name: 5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione
• CAS No.: 773143-41-2
• Molecular Formula: C₁₀H₁₁N₃O₃S
• Molecular Weight: 253.282
• Mol file: 773143-41-2.mol

Synonyms:5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione

Chemical Property of 5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione

There total 3 articles about 5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

carbon disulfide (75-15-0,12122-00-8) + 2-amino-4,5-dimethoxybenzohydrazide (37429-98-4) → 5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione (773143-41-2)

Guidance literature:

With potassium hydroxide; In ethanol; at 50 - 60 ℃;

DOI:10.3797/scipharm.aut-03-28

Reference yield:

methyl 2-amino-4,5-dimethoxybenzoate (26759-46-6) → 5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione (773143-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / aq. hydrazine hydrate / Heating

2: 57 percent / aq. potassium hydroxide / ethanol / 50 - 60 °C

With potassium hydroxide; hydrazine hydrate; In ethanol;

DOI:10.3797/scipharm.aut-03-28

Reference yield:

2-Amino-4,5-dimethoxybenzoic acid (5653-40-7) → 5-(2-amino-4,5-dimethoxy-phenyl)-3H-[1,3,4]oxadiazole-2-thione (773143-41-2)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 14 h / Heating

2: 95 percent / aq. hydrazine hydrate / Heating

3: 57 percent / aq. potassium hydroxide / ethanol / 50 - 60 °C

With potassium hydroxide; thionyl chloride; hydrazine hydrate; In ethanol;

DOI:10.3797/scipharm.aut-03-28

upstream raw materials:

carbon disulfide

2-amino-4,5-dimethoxybenzohydrazide

methyl 2-amino-4,5-dimethoxybenzoate

2-Amino-4,5-dimethoxybenzoic acid