methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Base Information

Chemical Name:methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate
CAS No.:1380312-73-1
Molecular Formula:C₃₅H₅₉N₃O₁₀Si₂
Molecular Weight:738.039
Hs Code.:

methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Synonyms:methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Suppliers and Price of methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

There total 8 articles about methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1380312-71-9
(1R,2R,3S,4S,5R,6R)-2-(benzyloxycarbonylamino)-5,6-bis(tertbutyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxylic acid

: 1380312-73-1
methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201200103

Reference yield:

: 1380312-72-0
methyl 2-[(1R,2R,3S,4S,5R,6R)-2-(benzyloxycarbonylamino)-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidendioxy)cyclohexanecarboxamido]acetate

: 1380312-73-1
methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

2: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201200103

Reference yield:

: C₁₅H₁₉NO₈

: 1380312-73-1
methyl 2-{(1R,2R,3S,4S,5R,6R)-2-[2-(benzyloxycarbonylamino)acetamido]-5,6-bis(tert-butyldimethylsilyloxy)-3,4-(isopropylidenedioxy)cyclohexanecarboxamido}acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid; copper(II) sulfate / acetone / 24 h / 20 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen; citric acid / methanol / 48 h / 20 °C / 760.05 Torr

3.1: sodium hydrogencarbonate / methanol; water / 3 h / 0 - 20 °C / Inert atmosphere

4.1: barium hydroxide octahydrate / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere

5.1: 1H-imidazole / methanol; N,N-dimethyl-formamide / 17 h / 80 °C / Inert atmosphere

6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

6.2: 12 h / 20 °C / Inert atmosphere

7.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / Inert atmosphere

With 1H-imidazole; barium hydroxide octahydrate; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; copper(II) sulfate; N-ethyl-N,N-diisopropylamine; citric acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;
DOI:10.1002/ejoc.201200103