N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester

Base Information

• Chemical Name: N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester
• CAS No.: 95765-85-8
• Molecular Formula: C₁₅H₁₈N₂O₅S
• Molecular Weight: 338.384
• Mol file: 95765-85-8.mol

Synonyms:N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester

Chemical Property of N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester

There total 4 articles about N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-<3-<(chloroacetyl)amino>benzoyl>glycine ethyl ester (95765-84-7) + potassium thioacetate (10387-40-3) → N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester (95765-85-8)

Guidance literature:

In ethanol; at 55 - 60 ℃; for 16h;

DOI:10.1021/jm00145a011

Reference yield:

3-<(chloroacetyl)amino>benzoic acid (28547-08-2) → N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester (95765-85-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / SOCl₂, pyridine / CHCl₃ / 2 h / 55 - 60 °C

2: 1.) NaHCO₃ / 1.) water, RT, 0.5 h, 2.) water, methanol, 16 h

3: 84 percent / ethanol / 16 h / 55 - 60 °C

With pyridine; thionyl chloride; sodium hydrogencarbonate; In ethanol; chloroform;

DOI:10.1021/jm00145a011

Reference yield:

3-<(chloroacetyl)amino>benzoyl chloride (67852-69-1) → N-<3-<<(acethylthio)cetyl>amino>benzoyl>glycine ethyl ester (95765-85-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaHCO₃ / 1.) water, RT, 0.5 h, 2.) water, methanol, 16 h

2: 84 percent / ethanol / 16 h / 55 - 60 °C

With sodium hydrogencarbonate; In ethanol;

DOI:10.1021/jm00145a011

upstream raw materials:

N-<3-<(chloroacetyl)amino>benzoyl>glycine ethyl ester

potassium thioacetate

3-<(chloroacetyl)amino>benzoic acid

3-<(chloroacetyl)amino>benzoyl chloride

Downstream raw materials:

N-<3-<(mercaptocetyl)amino>benzoyl>glycine ethyl ester