Z-BETA-TBU-D-ALA-OH DCHA

Base Information

• Chemical Name: Z-BETA-TBU-D-ALA-OH DCHA
• CAS No.: 201677-20-5
• Molecular Formula: C₁₅H₂₁NO₄
• Molecular Weight: 279.336
• Mol file: 201677-20-5.mol

Synonyms:N-ALPHA-CARBOBENZOXY-D-GAMMA-METHYL-LEUCINE DICYCLOHEXYLAMMONIUM SALT;N-ALPHA-CARBOBENZOXY-D-T-BUTYL-ALANINE DCHA;Z-D-NEOPENTYLGLYCINE DICYCLOHEXYLAMMONIUM SALT;Z-D-NEOPENTYLGLY-OH DCHA;Z-D-LEU(ME)-OH DCHA;Z-D-BETA-TBU-ALA-OH DCHA;Z-D-ALA(TBU)-OH DCHA;Z-BETA-TBU-D-ALANINE DCHA

Chemical Property of Z-BETA-TBU-D-ALA-OH DCHA

Chemical Property:

• Appearance/Colour: Oil
• PSA: 87.66000
• LogP: 6.82540
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Z-β-tert-butyl-D-alanine·DCHA,98%(HPLC) 98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-BETA-TBU-D-ALA-OH DCHA

There total 13 articles about Z-BETA-TBU-D-ALA-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-2-Amino-4,4-dimethyl-pentanoic acid (57224-50-7) + benzyl chloroformate (501-53-1,94274-21-2) → 2S-2-benzyloxycarbonylamino-2-t-butylmethyl-acetic acid (88319-44-2,201677-20-5)

Guidance literature:

With sodium hydroxide; In water;

Reference yield:

(R)-N-benzyloxycarbonyl-α-neopentylglycine D-phenylglycinol salt → (R)-N-benzyloxycarbonyl-α-neopentylglycine (201677-20-5)

Guidance literature:

With hydrogenchloride; In tert-butyl methyl ether; water; at 0 - 5 ℃; for 0.5h; pH=2 - 3;

Reference yield:

(E)-2-cyano-4,4-dimethyl-pent-2-enoic acid (39168-28-0) → N-benzoyloxycarbonyl-L-neopentylglycine (88319-44-2,201677-20-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 98 percent / H₂ / palladium black / acetic acid / 11.5 h

2: 50 percent / H₂O₂ / aq. KOH / 2 h

3: 100 percent / Br₂/aq. NaOH / 2 h / 30 - 40 °C

4: Ac₂O / 2 h / 0 - 5 °C

5: 100 percent / 10percent Aq_.HBr / 2 h / 100 °C

6: Aq_. NaOH / 2 h / Ambient temperature

With sodium hydroxide; hydrogen bromide; hydrogen; dihydrogen peroxide; bromine; acetic anhydride; palladium; In potassium hydroxide; acetic acid;

upstream raw materials:

L-neopentylglycine

benzyl chloroformate

(E)-2-cyano-4,4-dimethyl-pent-2-enoic acid

3,3-dimethylbutyrylaldehyde

Refernces

• 1、 -. "HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS". Page/Page column 61. . Retrieved 2008/06/13.
• 2、 -. "Protease inhibitors". . . Retrieved 2008/06/13.