10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzoquinolizin-4-one

Base Information

• Chemical Name: 10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzo
• Molecular Formula: C₂₆H₂₃ClN₂O₃
• Molecular Weight: 446.933

Synonyms:10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzoquinolizin-4-one

Chemical Property of 10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzo

Chemical Property:

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There total 8 articles about 10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzoquinolizin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) + 10-Chloro-4-oxo-3-phenyl-4H-pyrido[2,1-a]isoquinoline-1-carbonyl chloride → 10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzoquinolizin-4-one (104604-65-1)

Guidance literature:

With triethylamine; In toluene; Yield given; Ambient temperature;

DOI:10.1002/hlca.19900730402

Reference yield:

7-chloroisoquinoline-1(2Η)-one (24188-74-7) → 10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzoquinolizin-4-one (104604-65-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 91 percent / P₂S₅ / pyridine / 1.5 h / Heating

2: 2) NEt₃ / 1) CH₂Cl₂, 45 min

3: 81 percent / toluene / 8 h / Heating

4: 96 percent / NaOH / methanol; H₂O / 24 h / Heating

5: SOCl₂ / 1 h / Ambient temperature

6: NEt₃ / toluene / Ambient temperature

With sodium hydroxide; thionyl chloride; tetraphosphorus decasulfide; triethylamine; In pyridine; methanol; water; toluene;

DOI:10.1002/hlca.19900730402

Reference yield:

5-chloro-2-methylbenzonitrile (50712-70-4) → 10-chloro-1-<<(S)-2-(methoxymethyl)pyrrolidin-1-yl>carbonyl>-3-phenyl-4H-benzoquinolizin-4-one (104604-65-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 67.7 percent / 2.25 h

2: 63 percent / konz. HCl / ethanol / Heating

3: 91 percent / P₂S₅ / pyridine / 1.5 h / Heating

4: 2) NEt₃ / 1) CH₂Cl₂, 45 min

5: 81 percent / toluene / 8 h / Heating

6: 96 percent / NaOH / methanol; H₂O / 24 h / Heating

7: SOCl₂ / 1 h / Ambient temperature

8: NEt₃ / toluene / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; tetraphosphorus decasulfide; triethylamine; In pyridine; methanol; ethanol; water; toluene;

DOI:10.1002/hlca.19900730402

upstream raw materials:

(2S)-2-(methoxymethyl)-1-pyrrolidine

7-chloroisoquinoline-1(2Η)-one

5-chloro-2-methylbenzonitrile

7-chloroisoquinoline-1(2H)-thione

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