((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

Base Information

Chemical Name:((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate
CAS No.:1425937-49-0
Molecular Formula:C₃₄H₆₂O₆SSi₂
Molecular Weight:655.1
Hs Code.:

((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

Synonyms:((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

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Chemical Property of ((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

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Technology Process of ((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

There total 10 articles about ((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1425937-46-7
((1S,2S,3R,4R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

: 1425937-49-0
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; potassium hydroxide; In methanol; for 2h;

Reference yield:

: 183073-00-9
(1S,2E)-1-pentyl-3-(1,1,1-tributylstannyl)-2-propenyl (1,1,1-triethylsilyl) ether

: 1425937-49-0
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; copper(l) cyanide; methyllithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -70 °C

1.2: 0.5 h / -70 °C

2.1: toluene-4-sulfonic acid / tetrahydrofuran; dichloromethane / 1.5 h / 25 °C / Cooling with ice

2.2: 1 h / 20 °C

3.1: 1H-imidazole / ethyl acetate / 20 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Inert atmosphere

4.2: 1.75 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

6.1: hydrogen; potassium hydroxide; 5%-palladium/activated carbon / methanol / 2 h

With 1H-imidazole; n-butyllithium; 5%-palladium/activated carbon; methyllithium; hydrogen; copper(l) cyanide; toluene-4-sulfonic acid; triethylamine; 9-bora-bicyclo[3.3.1]nonane; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate;

Reference yield:

: 1425937-59-2
(3R)-1-[3-(benzyloxy)benzyl]-5-oxo-3-(triethylsilyloxy)cyclopent-1-ene

: 1425937-49-0
((1S,2S,3R,4R)-2-(3-hydroxybenzyl)-4-(tert-butyldimethylsilyloxy)-3-((3S,1E)-3-(tert-butyldimethylsilyloxy)oct-1-enyl)cyclopentyl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; copper(l) cyanide; methyllithium / diethyl ether; hexane; tetrahydrofuran / 0.5 h / -70 °C

1.2: 0.5 h / -70 °C

2.1: toluene-4-sulfonic acid / tetrahydrofuran; dichloromethane / 1.5 h / 25 °C / Cooling with ice

2.2: 1 h / 20 °C

3.1: 1H-imidazole / ethyl acetate / 20 °C

4.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 °C / Inert atmosphere

4.2: 1.75 h / 0 - 20 °C

5.1: triethylamine / dichloromethane / 0 °C / Inert atmosphere

6.1: hydrogen; potassium hydroxide; 5%-palladium/activated carbon / methanol / 2 h

With 1H-imidazole; n-butyllithium; 5%-palladium/activated carbon; methyllithium; hydrogen; copper(l) cyanide; toluene-4-sulfonic acid; triethylamine; 9-bora-bicyclo[3.3.1]nonane; potassium hydroxide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate;