(2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid

Base Information

Chemical Name:(2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid
CAS No.:155203-62-6
Molecular Formula:C₁₄H₁₇NO₃
Molecular Weight:247.294
Hs Code.:

Synonyms:(2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid

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Chemical Property of (2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid

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Technology Process of (2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid

There total 1 articles about (2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 155203-58-0
(2R,2'R,3'aS,7'S)-N-(3',3'a,4',5',6',7'-hexahydro-2'-phenyl-2'H-isooxazolo<2,3a>-pyridine-7'-carbonyl)bornane-10,2-sultam

: 108448-77-7,124224-04-0
(+)-camphorsultam

: 155203-62-6
(2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 55 ℃; for 30h;
DOI:10.1002/hlca.19940770217

Reference yield:

: 155203-62-6
(2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid

: 543-27-1
isobutyl chloroformate

: C₁₉H₂₅NO₅

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; at -15 ℃; for 0.166667h;
DOI:10.1002/hlca.19940770217

Reference yield:

: 155203-62-6
(2R,3aS,7S)-3,3a,4,5,6,7-hexahydro-2-phenyl-2H-isoxazolo<2,3-a>pyridine-7-carboxylic acid

: (2R,3aS,7S)-2-cyano-3,3a,4,5,6,7-hexahydro-8-methyl-2-phenyl-2H-isoxazolo<2,3-a>-1-pyridinium trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: NH₃ / tetrahydrofuran / -15 deg C, 30 min, and room t.

3: 91 percent / (CF₃CO)2O, pyridine / dioxane / 7-10 deg C then room t., 1 h

4: CH₂Cl₂ / -10 deg C, 20 min and room t., 30 min

With 4-methyl-morpholine; pyridine; ammonia; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1002/hlca.19940770217