butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

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Chemical Name:butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate
CAS No.:1428986-21-3
Molecular Formula:C₂₄H₂₅F₄N₅O₃
Molecular Weight:507.488
Hs Code.:

Synonyms:butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

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Chemical Property of butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

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Technology Process of butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

There total 7 articles about butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 94-25-7
4-amino-benzoic acid butyl ester

: 1428986-20-2
5-fluoro-4-[1-(tetrahydro-2H-puran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-chloride

: 1428986-21-3
butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

Guidance literature:: With palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; at 60 ℃; Inert atmosphere;
DOI:10.1021/op300365e

Reference yield:

: 1428986-19-9
1-(tetrahydro-2H-pyran-4-yl)-2-trifluoromethyl-1H-imidazole

: 1428986-21-3
butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-hexyllithium / tetrahydrofuran / 0.58 h / -25 - -15 °C / Inert atmosphere

1.2: 1.5 h / -25 - -15 °C

2.1: copper diacetate; oxygen; triethylamine / acetonitrile

3.1: potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 60 °C / Inert atmosphere

With oxygen; copper diacetate; n-hexyllithium; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/op300365e

Reference yield:

: 1005498-91-8
tetrahydro-2H-pyran-4-amine acetate

: 1428986-21-3
butyl 4-({5-fluoro-4-[1-(tetrahydro-2H-pyran-4-yl)-2-(trifluoromethyl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / toluene / 25 °C

2.1: triethylamine / toluene / 8 h / 50 °C

3.1: toluene / 25 °C

4.1: sulfuric acid / tetrahydrofuran / 5 h / 20 - 25 °C

5.1: n-hexyllithium / tetrahydrofuran / 0.58 h / -25 - -15 °C / Inert atmosphere

5.2: 1.5 h / -25 - -15 °C

6.1: copper diacetate; oxygen; triethylamine / acetonitrile

7.1: potassium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / tetrahydrofuran / 60 °C / Inert atmosphere

With sulfuric acid; oxygen; copper diacetate; n-hexyllithium; palladium diacetate; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.1021/op300365e