1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Base Information

Chemical Name:1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea
CAS No.:1402581-55-8
Molecular Formula:C₂₄H₂₈F₂N₄O₃
Molecular Weight:458.508
Hs Code.:

Synonyms:1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

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Chemical Property of 1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

There total 9 articles about 1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402585-67-4
(3-tert-butyl-1-(4-fluorophenyl)-1H-pyrazol-5-yl)methanamine

: 2-(4-(benzoyloxyamino)-2-fluorobenzyloxy)ethanol

: 1402581-55-8
1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Guidance literature:: With triethylamine; In acetonitrile; for 16h; Reflux;

Reference yield:

: 392-09-6
2-fluoro-4-nitro-benzoic acid methyl ester

: 1402581-55-8
1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; sodium tetrahydroborate / 4 h / 23 °C

2: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 2 h / 0 - 23 °C

3: sodium hydride / 16 h / 23 °C

4: hydrogen; palladium 10% on activated carbon / tetrahydrofuran / 16 h

5: pyridine / acetone / 1 h / 0 - 23 °C

6: triethylamine / acetonitrile / 16 h / Reflux

With pyridine; methanol; sodium tetrahydroborate; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1402581-55-8
1-[[5-tert-butyl-2-(4-fluorophenyl)-2H-pyrazol-3-yl]methyl]-3-[3-fluoro-4-(2-hydroxyethoxymethyl)phenyl]urea

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; copper diacetate / dichloromethane / 48 h / 23 °C

2: trifluoroacetic acid / dichloromethane / 23 °C

3: triethylamine / acetonitrile / 16 h / Reflux

With pyridine; copper diacetate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;