2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole

Base Information

• Chemical Name: 2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole
• CAS No.: 912458-15-2
• Molecular Formula: C₁₇H₁₉BrN₆O₃
• Molecular Weight: 435.28
• Mol file: 912458-15-2.mol

Synonyms:2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole

Chemical Property of 2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole

There total 10 articles about 2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.3%

2-[(2-bromo-4,6-dinitrophenyl)azo]-4-methoxy-5-[(2-hydroxyethyl)amino]acetanilide (26021-21-6) → 2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole (912458-15-2)

Guidance literature:

With sodium dithionite; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

DOI:10.1021/tx0000264

Reference yield:

Trifluoro-acetic acid 2-[(2-methoxy-5-nitro-phenyl)-(2,2,2-trifluoro-acetyl)-amino]-ethyl ester → 2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole (912458-15-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: H₂ / 5 percent Pd/C / ethyl acetate

2.1: K₂CO₃ / ethyl acetate / 1 h

3.1: 670 mg / K₂CO₃; MeOH / 2 h / 0 °C

4.1: NaNO₂; H₂SO₄

4.2: 85 percent / H₂SO₄

5.1: 5.3 percent / aq. Na₂S₂O₄ / tetrahydrofuran; methanol / 1 h / 20 °C

With methanol; sodium dithionite; sulfuric acid; hydrogen; potassium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1021/tx0000264

Reference yield:

N-benzylidene-2-methoxy-5-nitroaniline (385447-56-3) → 2-[2-(acetylamino)-4-[(2-hydroxyethyl)amino]-5-methoxyphenyl]-6-amino-4-bromo-2H-benzotriazole (912458-15-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 5 h / 80 °C

2.1: 9.54 g / H₂O / 1 h / 100 °C

3.1: K₂CO₃ / CH₂Cl₂ / 1 h / 20 °C

4.1: H₂ / 5 percent Pd/C / ethyl acetate

5.1: K₂CO₃ / ethyl acetate / 1 h

6.1: 670 mg / K₂CO₃; MeOH / 2 h / 0 °C

7.1: NaNO₂; H₂SO₄

7.2: 85 percent / H₂SO₄

8.1: 5.3 percent / aq. Na₂S₂O₄ / tetrahydrofuran; methanol / 1 h / 20 °C

With methanol; sodium dithionite; sulfuric acid; water; hydrogen; potassium carbonate; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;

DOI:10.1021/tx0000264

upstream raw materials:

2-[(2-bromo-4,6-dinitrophenyl)azo]-4-methoxy-5-[(2-hydroxyethyl)amino]acetanilide

3-amino-4-methoxynitrobenzene

N-benzylidene-2-methoxy-5-nitroaniline

3-[(2-hydroxyethyl)amino]-4-methoxynitrobenzene