4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol

Base Information

• Chemical Name: 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol
• CAS No.: 884872-42-8
• Molecular Formula: C₂₃H₁₅ClFN₃O₂S
• Molecular Weight: 451.908

Synonyms:4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol

Chemical Property of 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol

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Technology Process of 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol

There total 1 articles about 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-{N-(3-chloro-4-(3-fluoro-benzyloxy)phenylamino)}-5,8-dihydro-6H-benzo[4,5]thieno[2,3-d]pyrimidin-7-one (878018-21-4) → 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol (884872-42-8)

Guidance literature:

With 1-oxothiolane; at 100 ℃; for 2h; Product distribution / selectivity;

Reference yield: 80.0%

4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol (884872-42-8) + (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate (23788-74-1,7305-59-1) → [3-chloro-4-(3-fluorobenzyloxy)phenyl]-[7-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)benzo[4,5]thieno[2,3-d]pyrimidin-4-yl]amine

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield: 29.0%

2-(morpholin-4-yl)ethanol (622-40-2) + 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol (884872-42-8) → N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-7-(2-morpholin-4-ylethoxy)[1]benzothieno[2,3-d]pyrimidin-4-amine

Guidance literature:

With diamide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 15h;

upstream raw materials:

4-{N-(3-chloro-4-(3-fluoro-benzyloxy)phenylamino)}-5,8-dihydro-6H-benzo[4,5]thieno[2,3-d]pyrimidin-7-one

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