(S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

Base Information

Chemical Name:(S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione
CAS No.:1356224-45-7
Molecular Formula:C₁₇H₁₇NO₆S
Molecular Weight:363.391
Hs Code.:

Synonyms:(S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

Suppliers and Price of (S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

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Technology Process of (S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

There total 6 articles about (S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1356214-23-7
(3S)-5-oxo-1-(3-(5-(phenylthio)furan-2-yl)propyl)pyrrolidine-2,3-diyl diacetate

: 1356224-45-7
(S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

Guidance literature:: With dihydrogen peroxide; acetic acid; In water; at 20 ℃; for 48h;
DOI:10.1016/j.tet.2011.11.055

Reference yield:

: 3-(5-(phenylthio)furan-2-yl)acrylonitrile

: 1356224-45-7
(S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; nickel(II) chloride hexahydrate; di-tert-butyl dicarbonate / methanol / 0 - 20 °C

2.1: lithium aluminium tetrahydride / diethyl ether / 1.25 h / 0 °C

3.1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 180 °C / Azeotropic water removal

4.1: sodium tetrahydroborate / ethanol; dichloromethane / 1 h / -40 °C

4.2: -40 - 20 °C

5.1: pyridine; dmap / 16 h / 20 °C

6.1: dihydrogen peroxide; acetic acid / water / 48 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; nickel(II) chloride hexahydrate; di-tert-butyl dicarbonate; dihydrogen peroxide; acetic acid; In methanol; 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2011.11.055

Reference yield:

: 1356214-15-7
3-(5-(phenylthio)furan-2-yl)propanenitrile

: 1356224-45-7
(S)-3-hydroxy-1-(3-(5-(phenylsulfonyl)furan-2-yl)propyl)pyrrolidine-2,5-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 1.25 h / 0 °C

2.1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 180 °C / Azeotropic water removal

3.1: sodium tetrahydroborate / ethanol; dichloromethane / 1 h / -40 °C

3.2: -40 - 20 °C

4.1: pyridine; dmap / 16 h / 20 °C

5.1: dihydrogen peroxide; acetic acid / water / 48 h / 20 °C

With pyridine; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; dihydrogen peroxide; acetic acid; In 5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1016/j.tet.2011.11.055