C₃₆H₄₈O₆Si

Base Information

• Chemical Name: C₃₆H₄₈O₆Si
• CAS No.: 795306-78-4
• Molecular Formula: C₃₆H₄₈O₆Si
• Molecular Weight: 604.859
• Mol file: 795306-78-4.mol

Synonyms:C₃₆H₄₈O₆Si

Chemical Property of C₃₆H₄₈O₆Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₄₈O₆Si

There total 19 articles about C₃₆H₄₈O₆Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C36H46O6Si (795306-34-2) → C36H48O6Si (795306-78-4)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 0.333333h;

DOI:10.1039/b410092a

Reference yield:

(R)-5-(3-Benzyloxy-1-hydroxy-propyl)-3-methyl-dihydro-furan-2-one → C36H48O6Si (795306-78-4)

Guidance literature:

Multi-step reaction with 14 steps

1.1: 88 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

2.1: 99 percent / LiBH₄; MeOH / tetrahydrofuran / 4 h / 0 °C

3.1: 82 percent / DMAP; Et₃N / CH₂Cl₂ / 2.75 h / -78 - 20 °C

4.1: NaH / dimethylformamide / 2.5 h / -50 - 20 °C

4.2: 24 percent / TBAF / tetrahydrofuran / 1 h

5.1: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 0.75 h / 0 °C

6.1: 89 percent / LiBH₄; aq. NH₄Cl / tetrahydrofuran / 3 h / 20 °C

7.1: 95 percent / TPAP; NMO; 4-Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

8.1: LDA / tetrahydrofuran / 0.42 h / -78 °C

8.2: tetrahydrofuran / 0.42 h

9.1: 114 mg / NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 4 h

10.1: Na₂HPO₄ / tetrahydrofuran; methanol / 0.08 h

10.2: Na/Hg / methanol; tetrahydrofuran / 1 h

11.1: 20.4 mg / PPTS / tetrahydrofuran; H₂O / 15 h

12.1: LiDBB / tetrahydrofuran / 0.08 h / -78 °C

13.1: 2.8 mg / TPAP; 4 Angstroem molecular sieves; NMO / 2-methyl-propan-2-ol; acetonitrile

14.1: 78 percent / DIBAL-H / CH₂Cl₂ / 0.33 h / -78 °C

With 1H-imidazole; methanol; dmap; disodium hydrogenphosphate; lithium borohydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; lithium 4,4′-di(tert-butyl)biphenyl; 4 A molecular sieve; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ammonium chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 8.2: Julia coupling;

DOI:10.1039/b410092a

Reference yield:

(3R,5R)-5-((R)-3-Benzyloxy-1-triisopropylsilanyloxy-propyl)-3-methyl-dihydro-furan-2-one (795306-62-6) → C36H48O6Si (795306-78-4)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 99 percent / LiBH₄; MeOH / tetrahydrofuran / 4 h / 0 °C

2.1: 82 percent / DMAP; Et₃N / CH₂Cl₂ / 2.75 h / -78 - 20 °C

3.1: NaH / dimethylformamide / 2.5 h / -50 - 20 °C

3.2: 24 percent / TBAF / tetrahydrofuran / 1 h

4.1: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 0.75 h / 0 °C

5.1: 89 percent / LiBH₄; aq. NH₄Cl / tetrahydrofuran / 3 h / 20 °C

6.1: 95 percent / TPAP; NMO; 4-Angstroem molecular sieves / CH₂Cl₂ / 0.5 h / 20 °C

7.1: LDA / tetrahydrofuran / 0.42 h / -78 °C

7.2: tetrahydrofuran / 0.42 h

8.1: 114 mg / NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 4 h

9.1: Na₂HPO₄ / tetrahydrofuran; methanol / 0.08 h

9.2: Na/Hg / methanol; tetrahydrofuran / 1 h

10.1: 20.4 mg / PPTS / tetrahydrofuran; H₂O / 15 h

11.1: LiDBB / tetrahydrofuran / 0.08 h / -78 °C

12.1: 2.8 mg / TPAP; 4 Angstroem molecular sieves; NMO / 2-methyl-propan-2-ol; acetonitrile

13.1: 78 percent / DIBAL-H / CH₂Cl₂ / 0.33 h / -78 °C

With methanol; dmap; disodium hydrogenphosphate; lithium borohydride; N-methyl-2-indolinone; tetrapropylammonium perruthennate; lithium 4,4′-di(tert-butyl)biphenyl; 4 A molecular sieve; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ammonium chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol; 7.2: Julia coupling;

DOI:10.1039/b410092a

upstream raw materials:

C₃₆H₄₆O₆Si

(3R,5R)-5-((R)-3-Benzyloxy-1-triisopropylsilanyloxy-propyl)-3-methyl-dihydro-furan-2-one

(2R,4R,5R)-7-Benzyloxy-2-methyl-5-triisopropylsilanyloxy-heptane-1,4-diol

(S)-4-Benzyl-3-((E)-(R)-7-benzyloxy-2-methyl-hept-4-enoyl)-oxazolidin-2-one

Downstream raw materials:

C₅₂H₇₇BrO₇Si₂